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Animal Physiology Core (JDC)

Director: Goodyear, Laurie, Ph.D.

Location: Joslin Diabetes Center, One Joslin Place, Boston, MA 02215

Core Summary:

The Joslin Animal Physiology Core provides technically advanced physiological evaluation of rodents for the study of diabetes, obesity, and their associated complications. With recent award of a Massachusetts Life Science grant, a new facility for the Animal Physiology Core Laboratory will be built in 2013 within the Joslin. This new facility will consolidate services in one facility and expand services provided by the Core. The design of this new facility allows external users without extensive quarantine procedures. The Core personnel offer their expertise in designing and executing a variety of physiological assessments. For any inquiries about Core services, please contact Core personnel.

  • Joslin Diabetes Center
Personnel/Contact Information:

Director: Goodyear, Laurie, Ph.D.
Phone: (617) 309-2573

Member: Clermont, Allen, M.S.
Role: Animal Physiology Core Assistant Director
Phone: (617) 732-2568

Member: Mulvey, Maura, B.S.
Role: Animal Physiology Core Research Assistant
Phone: (617) 309-4127

Facilities and Equipment:

Location of Core: Joslin Diabetes Center, One Joslin Place, Boston, MA 02215

Major Equipment:

  • Comprehensive Lab Animal Monitoring System
  • Diurnal Incubator
  • DSI Telemetry System
  • Dual Energy X-ray Absorptiometry scanner
  • IVIS SpectrumCT imaging system
  • Laser Doppler Perfusion Imaging system
  • Metabolic Cages
  • Non-Invasive Tail Cuff Blood Pressure System
  • OxyCycler System
  • Rodent Exercise Treadmills
  • Blood Pressure Monitoring

    The Animal Physiology Core personnel use non-invasive tail-cuff sensor and monitoring system for the measurement of systolic and diastolic blood pressure and heart rate.

  • Body Composition using DEXA

    The Dual Energy X-ray Absorptiometry (DEXA) scanner uses x-rays to assess lean and fat mass distribution, bone mineral density and bone length. Body composition by the DEXA scanner can be performed on mice and rats up to 55 grams in weight.

  • Energy Expenditure and Metabolism using the CLAMS system

    The CLAMS system allows for simultaneous measurement of numerous parameters including oxygen consumption (VO2), carbon dioxide (CO2) production, respiratory exchange ratio (RER), food and drinking behavior, activity level, and caloric heat production.

  • Exercise Procedures

    The Animal Physiology Core has treadmills and wheelcages for acute and long-term training. After training in their use, the researcher will use these independently.

  • IVIS Spectrum CT Imaging System Monitoring

    A new IVIS Spectrum CT imaging system is now being added to the Animal Physiology Core as part of the current expansion. This system uses novel optical imaging technology to facilitate non-invasive longitudinal monitoring of disease progression, cell trafficking and regulated gene expression patterns in living animals via bioluminescent and fluorescent reporters.

  • Metabolic Cages for By-product Collection

    The Metabolic Cages are used to collect by-products from an individual rodent as each chamber accurately separates urine from feces.

  • Physiological Measurements using Telemetry System

    The DSI Telemetry System uses implantable transmitters to measure a number of physiological parameters in mice. Some of these parameters include, but are not limited to, blood pressure and activity, heart rate and activity, and body temperature and activity - all of which are measured telemetrically from the appropriate transmitter inside the individual mouse.

  • Studies of Hypoxia and Hyperoxia using the OxyCycler

    The Animal Physiology Core provides equipment and training for users to investigate the effects of hypoxia and/or hyperoxia using the OxyCycler System (BioSpherix Systems).

  • Temperature Control Chamber Service

    Our recently acquired diurnal incubator chamber is used to study the physiological mechanisms of brown fat generation and activation at both thermoneutral and cold temperatures.

  • Vascular Studies

    A Laser Doppler Perfusion Imaging (LDPI) system is used to provide functional evidence for ischemia-induced changes in vascularization.

Departmental Web Link(s):

Last updated: 2013-04-02T15:46:13.454-05:00