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Genetically Modified NOD Mouse Core Facility (HMS)

Location: Harvard Medical School, Pathology, NRB 1052G, 77 Avenue Louis Pasteur, Boston, MA 02115

Core Summary:

The Genetically Modified NOD Mouse Core provides Center investigators, as well as researchers elsewhere, with access to transgenic and mutant lines derived from the NOD mouse model: some will be generated within the Core; others are established lines of proven experimental value that are maintained in the Core.

The Core will construct transgenic mice in strains that have a high susceptibility to diabetes (in particular in the NOD line). This includes trangenesis by conventional pronuclear injection or by delivery of RNAi cassettes on lentiviral vectors.

The Core will also provide a panel of existing transgenic and mutant lines. These lines are chosen because of their established interest in allowing the dissection of immunological tolerance in Type 1 Diabetes, and in response to Center investigator needs.

Institutions:
  • Harvard Medical School
  • JDRF Center on Immunological Tolerance in Type-1 Diabetes
Personnel/Contact Information:

PI: Benoist, Christophe, M.D., Ph.D.
Role: Professor of Pathology
Phone: (617) 432-7743
Email

Member: Hattori, Kimie
Role: Colony Manager (Existing strains)
Phone: (617) 432-7754
Email

Member: General Inquiries
Email

Services:
  • Maintainence and dissemination of transgenic and mutant mice

    Complete list and description of available transgenic mouse strains can be found at Genetically Modified NOD Mouse Core URL listed (http://cbdm.hms.harvard.edu/Transgenics/micelist.pdf).


Departmental Web Link(s):

Last updated: 2013-10-22T14:51:03.527-05:00