HSCI iPS Cell Core Facility
Director: Rossi, Derrick J., Ph.D.; Cowan, Chad A., Ph.D.
Location: Harvard University, Bauer Building Room B01, 7 Divinity Avenue, Cambridge, MA 02138
The HSCI iPS Core facility was created to accelerate research in the stem cell field by facilitating the derivation and distribution of iPS cell lines. Disease-specific iPS lines provide us with a unique opportunity to study the mechanisms of disease and ultimately to develop new treatments. The iPS Core serves as a repository for iPS cells produced by HSCI scientists and functions as a laboratory to produce disease-specific lines for sharing with the HSCI and broader research community.
Director: Rossi, Derrick J., Ph.D.
Phone: (617) 713-8900
Director: Cowan, Chad A., Ph.D.
Phone: (617) 496-5222
Role: HSCI iPS Core Facility Manager
Phone: (617) 496-8059
- Genome Editing of stem cells
-In 2013, a new service was launched, offering the generation of genome engineered hESC or hiPS lines. We currently offer TALEN or CRISPR genome editing technologies to generate knock-out or knock-in lines for repair or introduction of mutations.
Details about the genome editing services can be found here.
- Induced pluripotent cell line derivation
-We offer three non-integrating technologies (Sendai virus, miRNA and modified mRNA, and episomal vector) for reprogramming of a variety of somatic cell types.
Details about the cell derivation service can be found here
- Stem Cell Distribution
-The iPS Core serves as a repository for Harvard hESC lines and both control and disease-specific hiPS cell lines.
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