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Preclinical Murine Pharmacogenetics Core (BIDMC)

Director: Clohessy, John G., Ph.D.

Location: Beth Israel Deaconess Medical Center, CLS 0402, 330 Brookline Ave., Boston, MA, 02115

Core Summary:

Institutions:
  • Beth Israel Deaconess Medical Center
Personnel/Contact Information:

Director: Clohessy, John G., Ph.D.
Phone: (617) 735-2147
Email

Facilities and Equipment:

Location of Core: Beth Israel Deaconess Medical Center, CLS 0402, 330 Brookline Ave., Boston, MA, 02115

Major Equipment:

  • QIAxcel System
Services:
  • Cancer mouse model service

    Service provides mouse models for the study of new drugs, drug combinations and novel therapeutic modalities. Includes both the use of the facility's numerous in-house cancer mouse models, and the purchase and housing of desired commercial cancer mouse models for the investigator.

  • Drug administration service

    Service includes drug administration by oral gavage and IP, SC or IV injection.

  • Human tumor xenografts service

    Includes establishment of human tumor xenografts in immunodeficient mice as appropriate.

  • In vitro assays to validate drug target specificity

    Service includes: the design and implementation of in vitro assays to validate target specificity; target validation of agents or combinations of agents in cell culture in one or more murine and human tumor cell lines or mouse embryonic fibroblasts (MEFs) of various genotypes; use of several different assays depending upon the agent and type of information sought; availability of an extremely large number of genetically modified MEFs lines and human tumor cell lines in our frozen repository for these studies.

  • Mouse breeding service

  • Mouse genotyping service

  • Protocol development service

    Provides advice in the study design and development of operational plans to implement protocols. Fees vary for academic internal, academic external and corporate fees.

  • Study reporting service

    Fees vary for academic internal, academic external and corporate fees. Provides reports of data and/or any relevant information relating to what occurred on each study.

  • Tail vein injections service

    Fees vary for academic internal, academic external and corporate fees.

  • Tissue service

    Service includes: tissues collection, tissue harvest/dissection, and tissue pre-processing. Facility does not process tissue samples; upon tissue collection, samples are passed to a Histology Core for further processing.

    Fees vary for academic internal, academic external and corporate fees.


Departmental Web Link(s):

Last updated: 2013-04-30T09:45:36.584-05:00