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Translational Imaging Laboratory (McLean)

Location: McLean Imaging Center, McLean Hospital, 115 Mill St., Belmont, MA 02478

Core Summary:

The McLean Hospital Translational Imaging Laboratory aims to provide cutting edge magnetic resonance imaging, functional imaging, chemical imaging (spectroscopy), and multimodal imaging services to the Harvard Catalyst Community. We have 3 magnetic resonance (MR) scanners, an ultra high magnetic field (9.4 Tesla) dedicated animal scanner and 3.0 and 4.0 Tesla large bore human systems available for large animal scans. Our scanners are capable of conducting scans in animals ranging in size from mice to large dogs, and we have experience imaging mice, rats, rabbits, nonhuman primates, and several canine species. All 3 scanners have dedicated animal prep areas. We offer high level biophysics, engineering, and data analytic expertise, along with veterinary technologist anesthesia support.

Institutions:
  • McLean Hospital
Personnel/Contact Information:

Member: Kaufman, Marc J., Ph.D.
Role: Associate Professor of Psychiatry
Phone: (617) 855-3469
Email

Member: General Inquiries
Phone: (617) 855-3469

Facilities and Equipment:

Location of Core: McLean Imaging Center, McLean Hospital, 115 Mill St., Belmont, MA 02478

Major Equipment:

  • Siemens (3T) Prisma Large Bore MRI Scanner
  • Siemens (3T) Trio Large Bore MRI Scanner
  • Varian/Agilent (4T) Direct Drive Large Bore MRI Scanner
  • Varian/Agilent Ultra High Magnetic Field (9.4T) Direct Drive Animal MRI Scanner
Services:
  • 3.0 and 4.0T large animal functional MRI

    Our high field human scanners support functional MRI studies in large animals that don't fit into our 29 cm animal scanner bore.

  • 3.0 and 4.0T large animal phosphorus spectroscopy

    Our high field human scanners support phosphorus spectroscopy studies in large animals that don't fit into our 29 cm animal scanner bore.

  • 3.0 and 4.0T large animal proton spectroscopy

    Our high field human scanners support proton spectroscopy studies in large animals that don't fit into our 29 cm animal scanner bore.

  • 3.0 and 4.0T large animal structural and diffusion MRI

    Our high field human scanners support structural and diffusion MRI studies in large animals that don't fit into our 29 cm animal scanner bore.

  • 3.0 and 4.0T large animal X-nuclear spectroscopy

    Our high field human scanners are used for X-nuclear spectroscopy studies in animals that cannot fit into the 9.4T system 29 cm bore.

  • 9.4T Facility rodent, nonhuman primate, and small animal phosphorus spectroscopy

    Our 9.4T system offers ultra high spatial resolution for phosphorus metabolites including ATP, PCr, Pi, phospholipids, and can noninvasively measure pH and magnesium concentration.

  • 9.4T Facility rodent, nonhuman primate, and small animal proton spectroscopy

    Our 9.4T system offers ultra high spatial, temporal, and spectral resolution for standard anatomical and diffusion imaging, and proton magnetic resonance spectroscopy. Our MRS program specializes in detection and quantification of proton metabolites relevant to brain disorders including GABA, glutamate, glutamine, glycine, and NAA, and can support brain temperature measurements.

  • 9.4T Facility rodent, nonhuman primate, and small animal structural and diffusion MRI

    Our 9.4T Facility is dedicated to animal research studies and is located in a building exclusively used for animal imaging research.

  • 9.4T Facility rodent, nonhuman primate, and small animal X-nuclear spectroscopy

    In addition to phosphorus spectroscopy, we support fluorine, lithium, carbon, and other X-nuclear spectroscopy.

  • Animal to human translational research

    Our 4T and 9.4T systems operate using the same software package, enabling us to conduct comparable imaging studies across platforms in multiple animal species, as well as in humans.

  • Data analytic services

    We support data analyses using a number of analytic tools including BrainVoyager, FSL, SPM, Freesurfer, ImageJ, LCModel, and others, and we develop customized scripts.

  • Equipment (e.g., coils, holders) design and fabrication

    Our biophysicists and engineers have access to CAD software and a 3-D printer, enabling us to design and build customized animal handling equipment and transmit/receive coils.

  • MRI, DTI, MRS, and fMRI protocol development

    We offer services to help develop new imaging protocols and customize existing ones.

  • Veterinary anesthesiology

    Our trained veterinary technologist supports isoflurane, propofol, and ketamine anesthesia, and ancillary procedures (intravenous line placement, intubation).


Departmental Web Link(s):

Last updated: 2015-12-07T16:13:47.726-06:00