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BWH Medicinal Chemistry Core

Director: Chorev, Michael, Ph.D.

Location: Brigham & Women’s Hospital, Thorn Building, Rm 705, 20 Shattuck Street, Boston, MA 02115, Fax: (617) 582-6069

Core Summary:

The mission of the BWH Medicinal Chemistry Core is to serve the Partners HealthCare and non-Partners research communities providing expertise and knowhow to help investigators engage Medicinal Chemistry in their basic or translational studies in an efficient and cost-effective manner.

  • Brigham and Women's Hospital
Personnel/Contact Information:

Director: Chorev, Michael, Ph.D.
Phone: (617) 525-3146

Member: Freedman, Revital, Ph.D.
Role: Staff Chemist
Phone: (617) 525-3146

Member: Green, Ella D.
Role: Administrator
Phone: (617) 525-3145

Member: General Inquiries

Facilities and Equipment:

Location of Core: Brigham & Women’s Hospital, Thorn Building, Rm 705, 20 Shattuck Street, Boston, MA 02115, Fax: (617) 582-6069

Major Equipment:

  • Biotage Flash Liquid Chromatography system
  • Lyophilizer
  • Microbalance
  • Rota-evaporators
  • Waters-Alliance HPLC
  • Waters-Micromass LC-ESI-MS
  • Analytical Services

    Quality control of delivered compounds obtained from commercial vendors or other sources to establish their chemical purity and structural integrity.
    1H-, 13C-, 19F-NMR spectra, as well as 2D-NMR spectra
    • Mass Spectroscopy: high resolution and low resolution MS
    • Purity level by analytical HPLC

  • Consulting Services

    • Selection of libraries for screening
    • Selection of druggable hits
    • Literature and database searches
    • Search for commercially available derivatives or fragments for preliminary biological evaluation
    • Design of structure-activity relationship (SAR) studies
    • Design of synthetic pathways
    • Hit-to-lead and lead optimization
    • Outsourcing custom synthesis when needed
    - Selection of providers
    - Solicitation and analysis of quotes
    - Assessment of synthetic pathways feasibility and cost-efficiency
    - Design and development of statement-of-work (SOW) and deliverables specifications
    - Negotiation of contracts
    • Preliminary assessment of intellectual property positions

  • Organic Synthesis and Analytical Bench work

    • Preliminary testing of alternative synthetic pathways for feasibility and cost-efficiency
    • Execution of multi-step synthesis of small molecules
    • Custom synthesis of focused libraries and derivatizations for SAR studies
    • Improvement of physicochemical properties of lead candidates and molecular probes
    • Scaling-up synthesis of molecular probes and lead candidates to support in vitro and preliminary in vivo studies
    • Purification and analytical characterization of small molecules by MS and NMR

Departmental Web Link(s):

Last updated: 2014-04-09T16:51:19.823-05:00