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Pancreatic Islet Isolation Core (MGH)

Director: Lei, Ji, MD, MBA

Location: Rm 4702, Simches Building, 185 Cambridge Street, Boston, MA, 02114

Core Summary:

The purpose of Pancreatic Islet Isolation Core of Boston Area Diabetes Endocrinology Research Center (BADRC) is to provide high quality islets to the local diabetes research community. The laboratory is physically located at The Massachusetts General Hospital (MGH). It is a specialized services facility (per OMB Circular A-21) and the only lab in New England produces human pancreatic islets under current Good Manufacture Procedure (cGMP) standards. The manufacturing facility supports the MGH clinic islet transplant program, a member of the Consortium of Islet Transplantation (CIT) which is working to advance clinical islet transplantation from an experimental trial to a standard care procedure.

Since its inception in 2008, the MGH Pancreatic Islet Isolation Laboratory has processed more than 160 human pancreata the majority of which generated islets that were distributed to investigators across the US for use in basic research. In 2011, we expanded our program to provide autologous human islet isolation to patients undergoing total pancreatectomy for chronic pancreatitis that has not responded to conventional intervention. This processing service has been offered to outside institutions and to date, approximately 30 patients from Mass General, Brigham and Women’s Hospital and Dartmouth-Hitchcock Medical Center of Dartmouth Medical School have benefited from this innovative technology.

We have conducted a variety of experimental studies on pancreatic islet transplantation in primate, porcine and rodent models. We also collaborate with researchers nationally to provide high quality nonhuman primate (NHP) islets for research. Our extensive experience in areas such as tolerance induction, encapsulation of islets, large/small animal surgery, islet isolation, and animal care allow us to be an ideal resource center for related studies.

Institutions:
  • Boston Area Diabetes Endocrinology Research Center (BADERC)
  • Massachusetts General Hospital
Personnel/Contact Information:

Director: Lei, Ji, MD, MBA
Phone: (617) 643-5327
Email

PI: Markmann, James, MD, Ph.D.
Email

Services:
  • Clinical Services

    1. Allogeneic Human Islet Isolation for clinical transplantation to treat severe type I diabetes mellitus
    2. Autologous Human Islet Isolation for clinical transplantation to prevent surgical diabetes after a total pancreatectomy

  • Services for BADERC Investigators

    1. Research Human Islet Isolation to provide normal, type I/II diabetic pancreatic islets to researchers worldwide
    2. Large Animal Islet Isolation with expertise in NHP islet isolation and porcine islet isolation
    3. Small Animal Islet Isolation with expertise in mice and rat islet isolation of any strains and age
    4. Experimental Islet Transplant Models NHP and small animal transplantation models are well established and contracted research has been conducted at the facility for several years


Departmental Web Link(s):

Last updated: 2016-02-05T12:16:05.211-06:00