A searchable database of core laboratory facilities. Core Facilities

Cancer Pharmacology Core (DF/HCC)

Director: Supko, Jeffrey, Ph.D.

Location: Massachusetts General Hospital, 32 Fruit Street, Jackson Building, 10th Floor, Boston, MA 02125

Core Summary:

The Cancer Pharmacology Core provides DF/HCC investigators with the necessary expertise and resources to design and undertake pharmacokinetic studies in the context of phase I and phase II clinical trials, and preclinical investigations. The core has the ability to implement and validate previously developed analytical methods to quantify drugs and their metabolites in biological fluids as well as the capability to modify or develop entirely new assays when warranted. The core also offers comprehensive analysis of pharmacokinetic data as an additional service, including the estimation of pharmacokinetic parameters and identifying their relationship to pathophysiological variables and pharmacodynamic effects.

Institutions:
  • Dana-Farber/Harvard Cancer Center
  • Massachusetts General Hospital
Personnel/Contact Information:

Director: Supko, Jeffrey, Ph.D.
Phone: (617) 724-1970
Email

Services:
  • Correlation analysis service

    "Correlation analyses to assess the influence of pathophysiologic variables on PK parameters and associations between PK parameters and biological effects such as toxicity, biological correlates, and therapeutic response."

  • Drug analysis service

    "The development, validation, and application of analytical methods to measure drugs and their metabolites in biological fluids."

  • Experimental design service

    "Experimental design and protocol development."

  • Manuscript and presentation preparation service

  • Metabolite identification service

  • PK data analysis and interpretation service

  • Sample procedure development service

    "Establishing and implementing appropriate procedures for sample handling, processing, and storage prior to analysis."

  • Sample report service

    "Preparation of dosing and sample collection case report forms and sample labels."

  • Sample storage and tracking service

  • Study oversight service


Departmental Web Link(s):

Last updated: 2012-08-06T16:08:15.841-05:00