A searchable database of core laboratory facilities. Core Facilities

Specialized Histopathology Services Core (DF/HCC)

Director: Aster, Jon Christopher, M.D., Ph.D. (Longwood site); Stemmer-Rachamimov, Anat O., M.D. (MGH site)

Core Summary:

Tissue analysis is critical to validation and evaluation of animal models of human cancer, and human cancer tissues serve as the "operating system" for translational research. The facility supports a wide spectrum of cancer-relevant research, from basic studies on pathogenic mechanisms in cancer to translational research focused on the development of new tests for biomarkers that stratify patients and direct therapy.

The Specialized Histopathology (SHP) Core has two performance sites: Longwood, Directed by Jon Aster and based at the Brigham and Women’s Hospital and MGH, Directed by Anat Stemmer-Rachamimov and based at Massachusetts General Hospital East in Charlestown.

The SHP Core provides high-quality, timely, state-of-the-art technical and professional pathology services to investigators working in a variety of experimental organisms, including rodents, fish, and monkeys, as well as with human tissues. The Core performs routine histology and special histochemical stains, and also assists in experimental design and the development, application, and interpretation of biomarker tests and their results. Specific services include immunohistochemistry, immunofluorescent staining, in situ hybridization, and access to a laser capture microdissection system.

Performance Sites:
Specialized Histopathology Services- Longwood Core
Brigham and Women's Hospital
75 Frances Street, Thorn 604, 603b
Boston, MA 02115

Specialized Histopathology Services- MGH Core
Massachusetts General Hospital-East
13th Street, Building 149
Charlestown Navy Yard 6, Room 6122
Boston, MA 02129

  • Brigham and Women's Hospital
  • Dana-Farber/Harvard Cancer Center
  • Massachusetts General Hospital
Personnel/Contact Information:

Director: Aster, Jon Christopher, M.D., Ph.D. (Longwood site)
Phone: (617) 525-4406

Director: Stemmer-Rachamimov, Anat O., M.D. (MGH site)
Phone: (617) 726-5156

Member: Bowman, Teri
Role: Core Manager, Handles Technical Questions and General Inquiries for all Core Services
Phone: (617) 525-7442

Member: Wyner, Lauri
Role: Content Manager
Phone: (617) 432-4947

Member: Chaves, Francis
Role: MGH Core Manager, Handles Technical Questions and General Inquiries for All Core Services
Phone: (617) 726-5510

  • CLIA certified services (Longwood only)

  • Cutting and staining of paraffin-embedded and frozen OCT sections

  • Eye Pathology services (human and mouse) (MGH only)

  • Immunofluorescent staining (Longwood only)

  • Immunohistochemistry for both routine and novel markers

  • In situ hybridization, using chromogenic or radioactive detection methods (Longwood only)

  • Laser capture microdissection (Longwood only)

  • Tissue trimming, cassetting, processing, and embedding

Departmental Web Link(s):

Last updated: 2015-01-30T15:34:30.969-06:00